Biomimetic nanofibers can construct effective tissue-engineered intervertebral discs for therapeutic implantation

Junchuan Yang; Xinglong Yang; Le Wang; Wei Zhang; Wenbo Yu; Nuoxin Wang; Baogan Peng; Wenfu Zheng; Guang Yang; Xingyu Jiang

doi:10.1039/C7NR03944A

Biomimetic nanofibers can construct effective tissue-engineered intervertebral discs for therapeutic implantation

Junchuan Yang,†^ab Xinglong Yang,†^bc Le Wang,†^b Wei Zhang,^d Wenbo Yu,^b Nuoxin Wang,^b Baogan Peng,^d Wenfu Zheng,*^b Guang Yang

*^a and Xingyu Jiang

*^bc

Author affiliations

* Corresponding authors

^a National Engineering Research Center for Nano-Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
E-mail: yang_sunny@yahoo.com

^b CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, China
E-mail: zhengwf@nanoctr.cn, xingyujiang@nanoctr.cn

^c University of Chinese Academy of Sciences, Beijing, China

^d Department of Spinal Surgery, General Hospital of Armed Police Force, Beijing, China

Abstract

We present a total tissue engineered (TE) intervertebral disc (IVD) to address IVD degradation, which is a major cause of chronic neck and back pain. The TE IVD is comprised of an alginate hydrogel-based nucleus pulposus (NP) and hierarchically organized, concentric ring-aligned electrospun (ES) polycaprolactone (PCL)/poly (D,L-lactide-co-glycolide) (PLGA)/Collagen type I (PPC)-based annulus fibrosus (AF). The TE IVD exhibits excellent hydrophilicity to simulate highly hydrated native IVD. Long-term in vivo implantation assays demonstrate the excellent structural (shape maintenance, hydration, and integration with surrounding tissues) and functional (mechanical supporting and flexibility) performances of the TE IVD. Our study provides a novel approach for treating IVD degeneration.

Nanoscale

Biomimetic nanofibers can construct effective tissue-engineered intervertebral discs for therapeutic implantation

Abstract

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