Issue 11, 2018

Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

Abstract

Tetrahedral DNA nanostructures (TDNs) have gathered great attention and are being widely used in biomedicine. We demonstrated that autophagy increased after exposure to TDNs (250 nM) along with the up-regulation of several autophagy-related genes and proteins. TDNs enhanced cell autophagy through the PI3K/AKT/mTOR signaling pathway.

Graphical abstract: Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

Supplementary files

Article information

Article type
Communication
Submitted
07 Dec 2017
Accepted
02 Jan 2018
First published
02 Jan 2018

Chem. Commun., 2018,54, 1327-1330

Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

S. Shi, S. Lin, Y. Li, T. Zhang, X. Shao, T. Tian, T. Zhou, Q. Li and Y. Lin, Chem. Commun., 2018, 54, 1327 DOI: 10.1039/C7CC09397G

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