Issue 15, 2018
From the journal:

Chemical Communications

Direct chemiluminescence detection of circulating microRNAs in serum samples using a single-strand specific nuclease-distinguishing nucleic acid hybrid system†

Kai Ling, ORCID logo ‡*ab   Hongyan Jiang,‡b   Xue Huang,a   Yang Li,a   Juanjuan Lina  and  Fu-Rong Li*a  

* Corresponding authors

a Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen 518020, China
E-mail: kailing@stu.edu.cn, frli62@163.com

b Department of Pharmacy, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China

Abstract

We developed a microplate-based enhanced chemiluminescence system for the direct detection of circulating miRNAs. The system exhibited a high target sensitivity and specificity, with a detection limit of 3.02 fM.

Graphical abstract: Direct chemiluminescence detection of circulating microRNAs in serum samples using a single-strand specific nuclease-distinguishing nucleic acid hybrid system

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Article information

DOI
https://doi.org/10.1039/C7CC09087K
Article type
Communication
Submitted
26 Nov 2017
Accepted
29 Jan 2018
First published
29 Jan 2018

Chem. Commun., 2018,54, 1909-1912

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Direct chemiluminescence detection of circulating microRNAs in serum samples using a single-strand specific nuclease-distinguishing nucleic acid hybrid system

K. Ling, H. Jiang, X. Huang, Y. Li, J. Lin and F. Li, Chem. Commun., 2018, 54, 1909 DOI: 10.1039/C7CC09087K

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