A unimolecular channel formed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity

Pengyang Xin; Yonghui Sun; Huiyuan Kong; Yaodong Wang; Si Tan; Jingjing Guo; Tao Jiang; Wenpei Dong; Chang-Po Chen

doi:10.1039/C7CC06697J

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A unimolecular channel formed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity†

Pengyang Xin,

*^a Yonghui Sun,^a Huiyuan Kong,^a Yaodong Wang,^a Si Tan,^a Jingjing Guo,^a Tao Jiang,^a Wenpei Dong*^a and Chang-Po Chen*^a

Author affiliations

* Corresponding authors

^a Henan Engineering Laboratory of Chemical Pharmaceuticals & Biomedical Materials, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China
E-mail: pyxin27@163.com, dongwenpei@163.com, changpochen@yahoo.com

Abstract

Five unimolecular channels with different lengths are presented. The varying length of these channels has significant impact on their transmembrane transport properties, which are directly correlated with their antimicrobial activity and inversely correlated with their haemolytic toxicity. By further structural optimization, these new channels could reach high antimicrobial activity and very low haemolytic toxicity, with the potential to serve as systemic antibiotics.

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Article information

DOI: https://doi.org/10.1039/C7CC06697J
Article type: Communication
Submitted: 26 Aug 2017
Accepted: 29 Sep 2017
First published: 02 Oct 2017

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Chem. Commun., 2017,53, 11492-11495

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A unimolecular channel formed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity

P. Xin, Y. Sun, H. Kong, Y. Wang, S. Tan, J. Guo, T. Jiang, W. Dong and C. Chen, Chem. Commun., 2017, 53, 11492 DOI: 10.1039/C7CC06697J

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Chemical Communications

A unimolecular channel formed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity†

Abstract

Supplementary files

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A unimolecular channel formed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity

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