Issue 80, 2017
From the journal:

Chemical Communications

Rapid, sensitive, and in-solution screening of peptide probes for targeted imaging of live cancer cells based on peptide recognition-induced emission†

Jiayuan He,ab   Shilang Gui,ab   Yanyan Huang,*ab   Fang Hu,ab   Yulong Jin,ab   Yang Yu,ab   Guanxin Zhang,ab   Deqing Zhang ORCID logo *ab  and  Rui Zhao ORCID logo *ab  

* Corresponding authors

a CAS Key Laboratories of Analytical Chemistry for Living Biosystems and Organic Solids, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: zhaorui@iccas.ac.cn, yyhuang@iccas.ac.cn, dqzhang@iccas.ac.cn

b University of Chinese Academy of Sciences, Beijing, China

Abstract

A fast and sensitive method was established for an in-solution selection of cancer cell-targeting peptides at “single-residue resolution” by using the switchable fluorescence of tetraphenylethylene. The selected peptides have potential for biomarker tracing and can be used for targeted delivery of different cargos into living cancer cells.

Graphical abstract: Rapid, sensitive, and in-solution screening of peptide probes for targeted imaging of live cancer cells based on peptide recognition-induced emission

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Article information

DOI
https://doi.org/10.1039/C7CC06485C
Article type
Communication
Submitted
18 Aug 2017
Accepted
18 Sep 2017
First published
19 Sep 2017

Chem. Commun., 2017,53, 11091-11094

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Rapid, sensitive, and in-solution screening of peptide probes for targeted imaging of live cancer cells based on peptide recognition-induced emission

J. He, S. Gui, Y. Huang, F. Hu, Y. Jin, Y. Yu, G. Zhang, D. Zhang and R. Zhao, Chem. Commun., 2017, 53, 11091 DOI: 10.1039/C7CC06485C

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