Issue 74, 2017
From the journal:

Chemical Communications

Synthesis of ribosyl-ribosyl-adenosine-5′,5′′,5′′′(triphosphate)—the naturally occurring branched fragment of poly(ADP ribose)†

Qiang Liu,a   Hans. A. V. Kistemaker,a   Herman S. Overkleeft,a   Gijsbert A. van der Marela  and  Dmitri V. Filippov*a  

* Corresponding authors

a Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands
E-mail: filippov@chem.leidenuniv.nl

Abstract

Poly-adenosine diphosphate ribose (PAR) is a branched biopolymer that occurs as a result of post-translational modification of proteins. In 1981 Miwa et al. determined the structure of enzymatically prepared branched PAR. We present the first synthesis of the same branched PAR fragment and have shown by NMR that the structure proposed by Miwa is correct.

Graphical abstract: Synthesis of ribosyl-ribosyl-adenosine-5′,5′′,5′′′(triphosphate)—the naturally occurring branched fragment of poly(ADP ribose)

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Article information

DOI
https://doi.org/10.1039/C7CC05755E
Article type
Communication
Submitted
24 Jul 2017
Accepted
17 Aug 2017
First published
17 Aug 2017

Chem. Commun., 2017,53, 10255-10258

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Synthesis of ribosyl-ribosyl-adenosine-5′,5′′,5′′′(triphosphate)—the naturally occurring branched fragment of poly(ADP ribose)

Q. Liu, Hans. A. V. Kistemaker, H. S. Overkleeft, G. A. van der Marel and D. V. Filippov, Chem. Commun., 2017, 53, 10255 DOI: 10.1039/C7CC05755E

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