Issue 63, 2017
From the journal:

Chemical Communications

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA†

Pawan Kumar,*a   Afaf H. El-Sagheer,ab   Lynda Truonga  and  Tom Brown ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, UK
E-mail: tom.brown@chem.ox.ac.uk

b Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt

Abstract

Oligonucleotides containing internal triazole–3′-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 5′-side of the triazole does not stabilise duplexes. Triazole–LNA confers great resistance towards enzymatic degradation relative to LNA alone.

Graphical abstract: Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

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Article information

DOI
https://doi.org/10.1039/C7CC05159J
Article type
Communication
Submitted
04 Jul 2017
Accepted
17 Jul 2017
First published
27 Jul 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 8910-8913

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Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

P. Kumar, A. H. El-Sagheer, L. Truong and T. Brown, Chem. Commun., 2017, 53, 8910 DOI: 10.1039/C7CC05159J

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