Issue 62, 2017

A targeted delivery strategy for the development of potent trypanocides

Abstract

A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei, the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting sequence that facilitated delivery of the molecular cargo to the appropriate organelle in the parasite.

Graphical abstract: A targeted delivery strategy for the development of potent trypanocides

Supplementary files

Article information

Article type
Communication
Submitted
01 May 2017
Accepted
14 Jul 2017
First published
14 Jul 2017

Chem. Commun., 2017,53, 8735-8738

A targeted delivery strategy for the development of potent trypanocides

H. M. Gordhan, J. E. Milanes, Y. Qiu, J. E. Golden, K. A. Christensen, J. C. Morris and D. C. Whitehead, Chem. Commun., 2017, 53, 8735 DOI: 10.1039/C7CC03378H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements