A selective and light-up fluorescent probe for β-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative

Guoyu Jiang; Guanjie Zeng; Wenping Zhu; Yongdong Li; Xiaobiao Dong; Guanxin Zhang; Xiaolin Fan; Jianguo Wang; Yongquan Wu; Ben Zhong Tang

doi:10.1039/C7CC00249A

A selective and light-up fluorescent probe for β-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative†

Guoyu Jiang,^a Guanjie Zeng,^a Wenping Zhu,^a Yongdong Li,^a Xiaobiao Dong,^b Guanxin Zhang,^b Xiaolin Fan,^a Jianguo Wang,

*^a Yongquan Wu*^a and Ben Zhong Tang*^c

Author affiliations

* Corresponding authors

^a Key Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, P. R. China
E-mail: wangjg@iccas.ac.cn

^b Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

^c Department of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

Abstract

An aggregation induced emission (AIE) based bioimaging probe, TPE-Gal, was designed for light-up imaging of β-galactosidase in living cells. The applicability of TPE-Gal in imaging endogenous β-galactosidase activity was confirmed in OVCAR-3 cells.

Chemical Communications

A selective and light-up fluorescent probe for β-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative†

Abstract

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A selective and light-up fluorescent probe for β-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative

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