Issue 8, 2017

Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy

Abstract

In this work, a potent photosensitizer, sinoporphyrin sodium (DVDMS), was loaded into RGD-modified ferritin (R-Fn) nanocages by a rapid, scalable and versatile approach for imaging guided photodynamic and photothermal (PTT/PDT) co-therapy. The resulting nanocomposite formed a well-defined nanocage with a photosensitizer loading capacity as high as 66.67 wt%, which far exceeds those reported previously. The bioengineered protein nanocage-based nanotheranostics exhibits a remarkably improved tumor treatment effect over DVDMS with good biocompatibility and the potential of clinical translation.

Graphical abstract: Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy

Supplementary files

Article information

Article type
Communication
Submitted
04 Apr 2017
Accepted
31 May 2017
First published
01 Jun 2017

Biomater. Sci., 2017,5, 1512-1516

Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy

C. Huang, C. Chu, X. Wang, H. Lin, J. Wang, Y. Zeng, W. Zhu, Y. J. Wang and G. Liu, Biomater. Sci., 2017, 5, 1512 DOI: 10.1039/C7BM00302A

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