Issue 12, 2016
From the journal:

Nanoscale

Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy†

M. Broekgaarden,‡a   R. van Vught,‡b   S. Oliveira,c   R. C. Roovers,c   P. M. P. van Bergen en Henegouwen,c   R. J. Pieters,d   T. M. Van Gulik,a   E. Breukinkb  and  M. Heger*a  

* Corresponding authors

a Department of Experimental Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
E-mail: m.heger@amc.uva.nl

b Department of Membrane Biochemistry and Biophysics, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

c Division of Cell Biology, Science Faculty, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

d Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P. O. Box 80082, Utrecht, The Netherlands

Abstract

Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested.

Graphical abstract: Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy

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Article information

DOI
https://doi.org/10.1039/C6NR00014B
Article type
Communication
Submitted
01 Jan 2016
Accepted
26 Feb 2016
First published
08 Mar 2016

Nanoscale, 2016,8, 6490-6494

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Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy

M. Broekgaarden, R. van Vught, S. Oliveira, R. C. Roovers, P. M. P. van Bergen en Henegouwen, R. J. Pieters, T. M. Van Gulik, E. Breukink and M. Heger, Nanoscale, 2016, 8, 6490 DOI: 10.1039/C6NR00014B

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