Issue 9, 2016
From the journal:

Molecular BioSystems

Inflammatory pathway network-based drug repositioning and molecular phenomics†

Jiangyong Gu,a   Philip S. Crosier,b   Christopher J. Hall,*b   Lirong Chen*a  and  Xiaojie Xu*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
E-mail: lirongc@pku.edu.cn, xiaojxu@pku.edu.cn

b Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland 1023, New Zealand
E-mail: c.hall@auckland.ac.nz

Abstract

Inflammation is a protective biological response to body/tissue damage that involves immune cells, blood vessels and molecular mediators. In this work, we constructed the pathway network of inflammation, including 11 sub-pathways of inflammatory factors. Pathway-based network efficiency and network flux were adopted to evaluate drug efficacy. By using approved and experimentally validated anti-inflammatory drugs as training sets, a predictive model was built to screen potential anti-inflammatory drugs from approved drugs in DrugBank. This drug repositioning approach would bring a fast and cheap way to find new indications for approved drugs. Moreover, molecular phenomics profiles of the expression of inflammatory factors will provide new insight into the drug mechanism of action.

Graphical abstract: Inflammatory pathway network-based drug repositioning and molecular phenomics

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Article information

DOI
https://doi.org/10.1039/C6MB00222F
Article type
Paper
Submitted
26 Mar 2016
Accepted
14 Jun 2016
First published
14 Jun 2016

Mol. BioSyst., 2016,12, 2777-2784

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Inflammatory pathway network-based drug repositioning and molecular phenomics

J. Gu, P. S. Crosier, C. J. Hall, L. Chen and X. Xu, Mol. BioSyst., 2016, 12, 2777 DOI: 10.1039/C6MB00222F

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