Issue 30, 2016
From the journal:

CrystEngComm

Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide†

T. N. Drebushchak,*ab   V. A. Drebushchak,bc   N. A. Pankrushinad  and  E. V. Boldyrevaa  

* Corresponding authors

a Institute of Solid State Chemistry and Mechanochemistry SB RAS, Kutateladze, 18, Novosibirsk, Russia
E-mail: tanya@xray.nsu.ru

b Novosibirsk State University, Pirogova, 2, Novosibirsk, Russia

c V. S. Sobolev Institute of Geology and Mineralogy SB RAS, Pr. Ak. Koptyuga, 3, Novosibirsk, Russia

d N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Pr. Ak. Lavrentieva, 9, Novosibirsk, Russia

Abstract

Three polymorphs of tolbutamide (IL, II, and III) were studied using single-crystal X-ray diffraction, from 100 K to room temperature (forms II and III) and to 350 K (form I), and differential scanning calorimetry. The reversible transformation, IL ⇔ IH, was found to be of the single-crystal to single-crystal type and the structure of the high-temperature form (IH) was solved and refined. The structure of IH differs from that of IL only in the conformation of the molecule, with molecular arrangements being practically unchanged (isostructural conformational transformation). The transition takes place at 313 K with no sign of hysteresis. The volume change, ΔV/V, across the reversible transformation IL ⇔ IH was calculated and compared to those for the other conformational transformations. Two types of conformational polymorphic transformations (irreversible reconstructive and reversible isostructural) in tolbutamide and chlorpropamide were compared.

Graphical abstract: Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide

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Article information

DOI
https://doi.org/10.1039/C6CE00764C
Article type
Paper
Submitted
04 Apr 2016
Accepted
15 Jun 2016
First published
15 Jun 2016
This article is Open Access
Creative Commons BY-NC license

CrystEngComm, 2016,18, 5736-5743

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Single-crystal to single-crystal conformational polymorphic transformation in tolbutamide at 313 K. Relation to other polymorphic transformations in tolbutamide and chlorpropamide

T. N. Drebushchak, V. A. Drebushchak, N. A. Pankrushina and E. V. Boldyreva, CrystEngComm, 2016, 18, 5736 DOI: 10.1039/C6CE00764C

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