Issue 13, 2017
From the journal:

Chemical Communications

Facile silicification of plastic surface for bioassays†

Seonki Hong, ORCID logo ab   Ki Soo Park, ORCID logo ab   Ralph Weissleder, ORCID logo abc   Cesar M. Castro ORCID logo *ad  and  Hakho Lee ORCID logo *ab  

* Corresponding authors

a Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA
E-mail: hlee@mgh.harvard.edu

b Department of Radiology, Massachusetts General Hospital, Boston, MA, USA

c Department of Systems Biology, Harvard Medical School, Boston, MA, USA

d Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
E-mail: castro.cesar@mgh.harvard.edu

Abstract

We herein report a biomimetic technique to modify plastic substrates for bioassays. The method first places a polydopamine adhesion layer to plastic surface, and then grows conformal silica coating. As proof of principle, we coated plastic microbeads to construct a disposable filter for point-of-care nucleic acid extraction.

Graphical abstract: Facile silicification of plastic surface for bioassays

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Article information

DOI
https://doi.org/10.1039/C6CC09359K
Article type
Communication
Submitted
23 Nov 2016
Accepted
23 Jan 2017
First published
30 Jan 2017

Chem. Commun., 2017,53, 2134-2137

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Facile silicification of plastic surface for bioassays

S. Hong, K. S. Park, R. Weissleder, C. M. Castro and H. Lee, Chem. Commun., 2017, 53, 2134 DOI: 10.1039/C6CC09359K

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