Issue 71, 2016
From the journal:

Chemical Communications

Gold(i)-catalyzed dehydrogenative cycloisomerization of 1,5-enynes†

Gen-Qiang Chen,a   Wei Fang,a   Yin Wei,a   Xiang-Ying Tang*a  and  Min Shi*a  

* Corresponding authors

a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China
E-mail: siocxiangying@sioc.ac.cn, mshi@mail.sioc.ac.cn

Abstract

The gold(I)-catalyzed dehydrogenative cycloisomerization of cyclopropane-tethered 1,5-enynes proceeded smoothly to give multisubstituted benzene derivatives in good to excellent yields. Synthetically important benzocyclobutenes can be produced in high yields in the presence of a gold(I) catalyst and DDQ. Furthermore, this reaction also works very well for non-cyclopropane tethered 1,5-enynes.

Graphical abstract: Gold(i)-catalyzed dehydrogenative cycloisomerization of 1,5-enynes

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Article information

DOI
https://doi.org/10.1039/C6CC05423D
Article type
Communication
Submitted
29 Jun 2016
Accepted
08 Aug 2016
First published
09 Aug 2016

Chem. Commun., 2016,52, 10799-10802

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Gold(I)-catalyzed dehydrogenative cycloisomerization of 1,5-enynes

G. Chen, W. Fang, Y. Wei, X. Tang and M. Shi, Chem. Commun., 2016, 52, 10799 DOI: 10.1039/C6CC05423D

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