Issue 85, 2016
From the journal:

Chemical Communications

Novel tubulin-targeted cell penetrating antimitotic octapeptide†

Debmalya Bhunia,‡a   Saswat Mohapatra,‡ab   Prashant Kurkute,a   Subhajit Ghosh,a   Batakrishna Jana,a   Prasenjit Mondal,ab   Abhijit Saha,a   Gaurav Dasa  and  Surajit Ghosh*ab  

* Corresponding authors

a Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India
E-mail: sghosh@iicb.res.in

b Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus, 4 Raja S. C. Mullick Road, Kolkata 700 032, India

Abstract

An antimitotic cell penetrating octapeptide containing single Arg amino acid is discovered, which strongly binds with the exchangeable GTP/GDP binding site of tubulin, inhibits tubulin polymerization, reduces kinesin driven microtubule motility, activates apoptotic and mitotic check point proteins, induces apoptotic death and significantly inhibits the multicellular tumor spheroid growth of HeLa cells.

Graphical abstract: Novel tubulin-targeted cell penetrating antimitotic octapeptide

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC05110C
Article type
Communication
Submitted
18 Jun 2016
Accepted
21 Sep 2016
First published
26 Sep 2016

Chem. Commun., 2016,52, 12657-12660

Permissions

Request permissions

Novel tubulin-targeted cell penetrating antimitotic octapeptide

D. Bhunia, S. Mohapatra, P. Kurkute, S. Ghosh, B. Jana, P. Mondal, A. Saha, G. Das and S. Ghosh, Chem. Commun., 2016, 52, 12657 DOI: 10.1039/C6CC05110C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements