Issue 69, 2016

Synthesis of 2,2′-biphenols through direct C(sp2)–H hydroxylation of [1,1′-biphenyl]-2-ols

Abstract

A novel synthesis of diversely substituted 2,2′-biphenols through Pd(II)-catalyzed, tBuOOH-oxidized, and hydroxyl-directed C(sp2)–H hydroxylation of [1,1′-biphenyl]-2-ols has been developed. Notably, this finding is distinct from previous reports in which [1,1′-biphenyl]-2-ols underwent an intramolecular C–H activation and C–O bond formation to afford dibenzofurans under the promotion of Pd(II) but in the absence of tBuOOH.

Graphical abstract: Synthesis of 2,2′-biphenols through direct C(sp2)–H hydroxylation of [1,1′-biphenyl]-2-ols

Supplementary files

Article information

Article type
Communication
Submitted
07 Jun 2016
Accepted
28 Jul 2016
First published
28 Jul 2016

Chem. Commun., 2016,52, 10529-10532

Synthesis of 2,2′-biphenols through direct C(sp2)–H hydroxylation of [1,1′-biphenyl]-2-ols

S. Duan, Y. Xu, X. Zhang and X. Fan, Chem. Commun., 2016, 52, 10529 DOI: 10.1039/C6CC04756D

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