Issue 60, 2016
From the journal:

Chemical Communications

Comparison of N-acetylcysteine and cysteine in their ability to replenish intracellular cysteine by a specific fluorescent probe†

Xinyuan He,ab   Xiaofeng Wu,ab   Wen Shi*ab  and  Huimin Ma*ab  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: shiwen@iccas.ac.cn, mahm@iccas.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

A specific fluorescent probe, designed by a substitution-rearrangement mechanism, can discriminate cysteine from other thiols. Using this probe, N-acetylcysteine is revealed to be superior to cysteine to replenish intracellular cysteine in cells.

Graphical abstract: Comparison of N-acetylcysteine and cysteine in their ability to replenish intracellular cysteine by a specific fluorescent probe

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Article information

DOI
https://doi.org/10.1039/C6CC04628B
Article type
Communication
Submitted
02 Jun 2016
Accepted
23 Jun 2016
First published
23 Jun 2016

Chem. Commun., 2016,52, 9410-9413

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Comparison of N-acetylcysteine and cysteine in their ability to replenish intracellular cysteine by a specific fluorescent probe

X. He, X. Wu, W. Shi and H. Ma, Chem. Commun., 2016, 52, 9410 DOI: 10.1039/C6CC04628B

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