Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy

Zexuan Ding; Peng Liu; Dehong Hu; Zonghai Sheng; Huqiang Yi; Guanhui Gao; Yayun Wu; Pengfei Zhang; Shaozhi Ling; Lintao Cai

doi:10.1039/C6BM00846A

Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy†

Zexuan Ding,‡^ab Peng Liu,‡^ac Dehong Hu,^a Zonghai Sheng,^a Huqiang Yi,^a Guanhui Gao,^a Yayun Wu,^a Pengfei Zhang,^a Shaozhi Ling^d and Lintao Cai

*^a

Author affiliations

* Corresponding authors

^a Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, P. R. China
E-mail: lt.cai@siat.ac.cn

^b Nano Science and Technology Institute, University of Science & Technology of China, Suzhou, P. R. China

^c Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge 117576, Singapore

^d General Hospital of Chinese Armed Police Forces, Beijing 100039, P.R. China

Abstract

Photodynamic therapy (PDT) is a site-specific treatment of cancer using much lower optical power densities with minimal nonspecific damage to normal tissues. To improve the therapeutic efficiency of PDT, we fabricated a multifunctional theranostic nanoparticle system (DSSCe6@Fe₃O₄ NPs) by loading Fe₃O₄ nanoparticles in redox-responsive chlorin e6 (Ce6)-conjugated dextran nanoparticles for near-infrared (NIR)/magnetic resonance (MR) dual-modality imaging and magnetic targeting. The obtained DSSCe6@Fe₃O₄ NPs demonstrated a uniform nanospherical morphology consisting of Fe₃O₄ clusters. The fluorescence signal of Ce6 of this theranostic system could turn “ON” from a self-quenching state in a reductive intracellular environment. T₂-Weighted MR imaging revealed a high transverse relaxivity (r₂) measured to be 194.4 S⁻¹ mM⁻¹, confirming that it was also a distinctive contrast agent in T₂-weighted MR imaging. Confocal images and flow cytometry results showed that the cellular uptake of DSSCe6@Fe₃O₄ NPs was enhanced effectively under an extra magnetic field, which resulted in promoted PDT therapeutic efficiency. In vivo MR imaging showed that DSSCe6@Fe₃O₄ NPs effectively accumulated in tumors under an extra magnetic field. These results illustrated that the DSSCe6@Fe₃O₄ NPs could be a promising theranostic system for both NIR/MR imaging-guided PDT precision therapy.

Biomaterials Science

Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy

Social activity

Search articles by author

Spotlight

Advertisements