Photodynamic therapy of oligoethylene glycol dendronized reduction-sensitive porphyrins

Lei Xu; Lichao Liu; Feng Liu; Wen Li; Ruobin Chen; Yun Gao; Weian Zhang

doi:10.1039/C5TB00276A

Photodynamic therapy of oligoethylene glycol dendronized reduction-sensitive porphyrins†

Lei Xu,^a Lichao Liu,^a Feng Liu,^a Wen Li,*^b Ruobin Chen,^b Yun Gao^a and Weian Zhang*^a

* Corresponding authors

^a Shanghai Key Laboratory of Functional Materials Chemistry, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China
E-mail: wazhang@ecust.edu.cn

^b Laboratory of Polymer Chemistry, Department of Polymer Materials, College of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Materials Building Room 433, Shanghai 200444, China
E-mail: wli@shu.edu.cn

Abstract

OEGylation of porphyrins via a disulfide linkage to form a novel class of dendritic porphyrin photosensitizers (PSs) is presented. These amphiphilic PSs possess precise molecular structures which could self-assemble into spherical aggregates in aqueous solutions. Their thermoresponsiveness was investigated using UV-Vis spectroscopy, and their reduction responsive properties were inspected using dynamic light scattering and TEM measurements. Moreover, the uptake of porphyrin-containing dendritic micelles by cells and release of reduction-sensitive PSs were investigated using flow cytometry and confocal laser scanning microscopy. The results showed that the cellular uptake of dendritic micelles was more than that of free porphyrin and the uptake process was time-dependent. Additionally, the phototoxicity of these dendritic PS micelles was investigated by MTT assay. It was found that dendritic micelles exhibited efficient phototoxicity to cancer cells while the free porphyrin had nearly no toxicity under light irradiation. All results indicate that these dendritic PSs are promising for photodynamic therapy.

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DOI: https://doi.org/10.1039/C5TB00276A
Article type: Paper
Submitted: 07 Feb 2015
Accepted: 25 Feb 2015
First published: 25 Feb 2015

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J. Mater. Chem. B, 2015,3, 3062-3071

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Photodynamic therapy of oligoethylene glycol dendronized reduction-sensitive porphyrins

L. Xu, L. Liu, F. Liu, W. Li, R. Chen, Y. Gao and W. Zhang, J. Mater. Chem. B, 2015, 3, 3062 DOI: 10.1039/C5TB00276A

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Journal of Materials Chemistry B

Photodynamic therapy of oligoethylene glycol dendronized reduction-sensitive porphyrins†

Abstract

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Photodynamic therapy of oligoethylene glycol dendronized reduction-sensitive porphyrins

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