Issue 3, 2016
From the journal:

RSC Advances

Triterpenes from the fruits of Rosa laevigata with acetylcholinesterase and Aβ-aggregation inhibitory activities†

Pin-Yi Gao,ab   Meng Wang,a   Xue-Gui Liu,*a   Yi-Xing Gao,a   Jia-Luo Li,a   Zhen-Xue Zhang,a   Hou-Wen Linc  and  Shao-Jiang Song*b  

* Corresponding authors

a College of Pharmaceutical and Biotechnology Engineering, Shenyang University of Chemical Technology, Shenyang 110142, P. R. China
E-mail: liuxuegui72@163.com, gpy1981@163.com

b Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China
E-mail: songsj99@163.com

c Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P. R. China

Abstract

A lupane-type triterpene (1) featuring a rare 2-hemiacetal moiety in its A ring and aromatic ester derivatives (2–6) were isolated from the fruits of R. laevigata and evaluated to possess acetylcholinesterase and Aβ-aggregation inhibitory activities. Their structures were determined by multi-spectroscopic methods, chemosynthesis and CD analysis.

Graphical abstract: Triterpenes from the fruits of Rosa laevigata with acetylcholinesterase and Aβ-aggregation inhibitory activities

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Article information

DOI
https://doi.org/10.1039/C5RA21590K
Article type
Communication
Submitted
16 Oct 2015
Accepted
21 Dec 2015
First published
23 Dec 2015

RSC Adv., 2016,6, 2431-2435

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Triterpenes from the fruits of Rosa laevigata with acetylcholinesterase and Aβ-aggregation inhibitory activities

P. Gao, M. Wang, X. Liu, Y. Gao, J. Li, Z. Zhang, H. Lin and S. Song, RSC Adv., 2016, 6, 2431 DOI: 10.1039/C5RA21590K

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