SCHEDULED MAINTENANCE
Synthesis of 1,1-diboronate esters by cobalt-catalyzed sequential hydroboration of terminal alkynes†
Abstract
A cobalt complex of iminopyridine-oxazoline catalyzes sequential hydroboration of alkyl and aryl alkynes with pinacolborane to form 1,1-diboronate esters. The reactions proceed under mild conditions with high yields, high regioselectivity, and wide functional group tolerance. The synthetic utility of 1,1-di(boronates) is demonstrated by chemoselective monoarylation and stepwise diarylation through palladium-catalyzed Suzuki–Miyaura coupling reactions.
- This article is part of the themed collections: Celebrating 70 Years of Shanghai Institute of Organic Chemistry and 2015 Emerging Investigators by OCF
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