Issue 3, 2016
From the journal:

Organic & Biomolecular Chemistry

Zn/Sc bimetallic relay catalysis: one pot cycloisomerization/carbonyl–ene reaction toward oxazole derivatives†

Bin Wang,a   Ying Chen,a   Ling Zhou,b   Jianwu Wang*a  and  Zhenghu Xu*ac  

* Corresponding authors

a Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China
E-mail: xuzh@sdu.edu.cn, jwwang@sdu.edu.cn

b Department of Chemistry and Biochemistry, Miami University, Oxford, OH, USA

c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

A novel tandem metal relay catalytic system combining Zn(II)-catalyzed cycloisomerization and a Sc(III)-catalyzed carbonyl–ene reaction has been successfully developed. By using this unprecedented Zn/Sc bimetallic relay catalytic system, a variety of oxazole derivatives were obtained from easily available N-(propargyl)arylamides and aldehydes under mild conditions.

Graphical abstract: Zn/Sc bimetallic relay catalysis: one pot cycloisomerization/carbonyl–ene reaction toward oxazole derivatives

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Article information

DOI
https://doi.org/10.1039/C5OB02158H
Article type
Communication
Submitted
19 Oct 2015
Accepted
16 Nov 2015
First published
17 Nov 2015

Org. Biomol. Chem., 2016,14, 826-829

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Zn/Sc bimetallic relay catalysis: one pot cycloisomerization/carbonyl–ene reaction toward oxazole derivatives

B. Wang, Y. Chen, L. Zhou, J. Wang and Z. Xu, Org. Biomol. Chem., 2016, 14, 826 DOI: 10.1039/C5OB02158H

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