Issue 40, 2015
From the journal:

Organic & Biomolecular Chemistry

Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers†

M. Glaffig,a   B. Palitzsch,a   N. Stergiou,b   C. Schüll,a   D. Straßburger,a   E. Schmitt,b   H. Freya  and  H. Kunz*a  

* Corresponding authors

a Johannes Gutenberg-University Mainz, Institute of Organic Chemistry, Duesbergweg 10-14, 55128 Mainz, Germany
E-mail: hokunz@uni-mainz.de

b University Medical Center, Institute of Immunology, Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, Geb. 708, 55101 Mainz, Germany

Abstract

Enhancing the immunogenicity of an antitumour vaccine still poses a major challenge. It depends upon the selected antigen and the mode of its presentation. We here describe a fully synthetic antitumour vaccine, which addresses both aspects. For the antigen, a tumour-associated MUC1 glycopeptide as B-cell epitope was synthesised and linked to the immunostimulating T-cell epitope P2 derived from tetanus toxoid. The MUC1-P2 conjugate is presented multivalently on a hyperbranched polyglycerol to the immune system. In comparison to a related vaccine of lower multivalency, this vaccine exposing more antigen structures on the hyperbranched polymer induced significantly stronger immune responses in mice and elicited IgG antibodies of distinctly higher affinity to epithelial tumour cells.

Graphical abstract: Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers

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Article information

DOI
https://doi.org/10.1039/C5OB01255D
Article type
Paper
Submitted
18 Jun 2015
Accepted
17 Aug 2015
First published
18 Aug 2015
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2015,13, 10150-10154

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Enhanced immunogenicity of multivalent MUC1 glycopeptide antitumour vaccines based on hyperbranched polymers

M. Glaffig, B. Palitzsch, N. Stergiou, C. Schüll, D. Straßburger, E. Schmitt, H. Frey and H. Kunz, Org. Biomol. Chem., 2015, 13, 10150 DOI: 10.1039/C5OB01255D

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