Issue 2, 2016

Gd-based upconversion nanocarriers with yolk–shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer

Abstract

Multidrug resistance (MDR) of cancers is still a major challenge, and it is very important to develop visualized nanoprobes for the diagnosis and treatment of drug resistant cancers. In this work, we developed a multifunctional delivery system based on DOX-encapsulated NaYF4:Yb/Er@NaGdF4 yolk–shell nanostructures for simultaneous dual-modal imaging and enhanced chemotherapy in drug resistant breast cancer. Using the large pore volume of the nanostructure, the delivery system had a high loading efficiency and excellent stability. Also, an in vitro and in vivo toxicity study showed the good biocompatibility of the as-prepared yolk–shell nanomaterials. Moreover, by nanocarrier delivery, the uptake of DOX could be greatly increased in drug resistant MCF-7/ADR cells. Compared with free DOX, the as-prepared delivery system enhanced the chemotherapy efficacy against MCF-7/ADR cells, indicating the excellent capability for overcoming MDR. Furthermore, core–shell NaYF4:Yb/Er@NaGdF4 improved the upconversion luminescence (UCL) performance, and the designed delivery system could also be applied for simultaneous UCL and magnetic resonance (MR) imaging, which could be a good candidate as a dual-modal imaging nanoprobe. Therefore, we developed a multifunctional yolk–shell delivery system, which could have potential applications as a visualized theranostic nanoprobe to overcome MDR in breast cancer.

Graphical abstract: Gd-based upconversion nanocarriers with yolk–shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer

Article information

Article type
Paper
Submitted
22 Sep 2015
Accepted
22 Nov 2015
First published
23 Nov 2015

Nanoscale, 2016,8, 878-888

Author version available

Gd-based upconversion nanocarriers with yolk–shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer

Y. Pan, L. Zhang, L. Zeng, W. Ren, X. Xiao, J. Zhang, L. Zhang, A. Li, G. Lu and A. Wu, Nanoscale, 2016, 8, 878 DOI: 10.1039/C5NR06522D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements