Issue 19, 2015

Doubly chloro bridged dimeric copper(ii) complex: magneto-structural correlation and anticancer activity

Abstract

We have synthesized and structurally characterized a new doubly chloro bridged dimeric copper(II) complex, [Cu2(μ-Cl)2(HL)2Cl2] (1) based on a Schiff base ligand, 5-[(pyridin-2-ylmethylene)-amino]-pentan-1-ol). Single crystal X-ray diffraction shows the presence of dinuclear copper(II) centres in a square pyramidal geometry linked by obtuse double chloro bridge. The magnetic study illustrated that weak antiferromagnetic interactions (J = −0.47 cm−1) prevail in complex 1 which is well supported by magneto-structural correlation. This compound adds to the library of doubly chloro bridged copper(II) complexes in the regime of spin state cross over. DFT calculations have been conducted within a broken-symmetry (BS) framework to investigate the exchange interaction further which depicts that the approximate spin projection technique yields the best corroboration of the experimental J value. Spin density plots show the presence of an ∼0.52e charge residing on the copper atom along with a substantial charge on bridging and peripheral chlorine atoms. The potential of complex 1 to act as an anticancer agent is thoroughly examined on a series of liver cancer cell lines and screening shows the HepG2 cell line exhibits maximum cytotoxicity by phosphatidyl serine exposure in the outer cell membrane associated with ROS generation and mitochondrial depolarization with increasing time in the in vitro model system.

Graphical abstract: Doubly chloro bridged dimeric copper(ii) complex: magneto-structural correlation and anticancer activity

Supplementary files

Article information

Article type
Paper
Submitted
20 Feb 2015
Accepted
27 Mar 2015
First published
27 Mar 2015

Dalton Trans., 2015,44, 8876-8888

Doubly chloro bridged dimeric copper(II) complex: magneto-structural correlation and anticancer activity

Y. Sikdar, R. Modak, D. Bose, S. Banerjee, D. Bieńko, W. Zierkiewicz, A. Bieńko, K. Das Saha and S. Goswami, Dalton Trans., 2015, 44, 8876 DOI: 10.1039/C5DT00752F

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