Issue 20, 2016

Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA

Abstract

A fluorophore displaying aggregation-induced emission was introduced at the terminus of branched polyethylenimine (PEI). The formulated polyplex not only demonstrated an improved safety profile and preserved transfection activity but also importantly indicated that the uncomplexed naked DNA rather than the polyplexes translocated into the nucleus.

Graphical abstract: Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA

Supplementary files

Article information

Article type
Communication
Submitted
28 Nov 2015
Accepted
13 Jan 2016
First published
15 Jan 2016

Chem. Commun., 2016,52, 3907-3910

Incorporation of an aggregation-induced-emissive tetraphenylethene derivative into cationic gene delivery vehicles manifested the nuclear translocation of uncomplexed DNA

X. Han, Q. Chen, H. Lu, P. Guo, W. Li, G. Wu, J. Ma and H. Gao, Chem. Commun., 2016, 52, 3907 DOI: 10.1039/C5CC09836J

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