Thiazolium carbene catalysts for the fixation of CO2 onto amines

Shoubhik Das; Felix D. Bobbink; Safak Bulut; Mylène Soudani; Paul J. Dyson

doi:10.1039/C5CC08741D

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Thiazolium carbene catalysts for the fixation of CO₂ onto amines†

Shoubhik Das,*^ab Felix D. Bobbink,^a Safak Bulut,^a Mylène Soudani^a and Paul J. Dyson*^a

Author affiliations

* Corresponding authors

^a Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland
E-mail: paul.dyson@epfl.ch

^b Institüt für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammann str. 2, Germany
E-mail: sdas@gwdg.de

Abstract

The catalytic N-formylation and N-methylation of amines using CO₂ as the carbon source represents a facile and sustainable approach for the synthesis of pharmaceuticals and natural products. Herein, we describe highly effective and inexpensive thiazolium carbene-based catalysts derived from vitamin B1 for the N-formylation and N-methylation of amines, using polymethylhydrosiloxane (PMHS) as a reducing agent, which operate under ambient conditions.

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Article information

DOI: https://doi.org/10.1039/C5CC08741D
Article type: Communication
Submitted: 21 Oct 2015
Accepted: 18 Dec 2015
First published: 18 Dec 2015
This article is Open Access

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Chem. Commun., 2016,52, 2497-2500

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Thiazolium carbene catalysts for the fixation of CO₂ onto amines

S. Das, F. D. Bobbink, S. Bulut, M. Soudani and P. J. Dyson, Chem. Commun., 2016, 52, 2497 DOI: 10.1039/C5CC08741D

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