Issue 99, 2015
From the journal:

Chemical Communications

The copper-catalyzed aerobic oxidative amidation of tertiary amines†

Hui-Cheng Cheng,a   Wen-Jun Hou,a   Zeng-Wen Li,a   Ming-Yu Liua  and  Bing-Tao Guan*a  

* Corresponding authors

a State Key Laboratory and Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China
E-mail: guan@nankai.edu.cn

Abstract

A general and efficient method for the synthesis of tertiary amides has been developed via the copper-catalyzed aerobic oxidative amidation of tertiary amines. Due to the use of the O2 oxidant, various functional groups were well tolerated under the present conditions. Extensive substrates studies demonstrated its potential as a practical approach for the synthesis of tertiary amides.

Graphical abstract: The copper-catalyzed aerobic oxidative amidation of tertiary amines

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Article information

DOI
https://doi.org/10.1039/C5CC07454A
Article type
Communication
Submitted
05 Sep 2015
Accepted
07 Oct 2015
First published
12 Oct 2015

Chem. Commun., 2015,51, 17596-17599

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The copper-catalyzed aerobic oxidative amidation of tertiary amines

H. Cheng, W. Hou, Z. Li, M. Liu and B. Guan, Chem. Commun., 2015, 51, 17596 DOI: 10.1039/C5CC07454A

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