Issue 96, 2015

Highly-efficient and versatile fluorous-tagged Cu(i)-catalyzed azide–alkyne cycloaddition ligand for preparing bioconjugates

Abstract

A novel ligand (FBTTBE) for Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) has been developed, which demonstrates not only superior catalytic efficiency but also the ease of removing toxic copper species. FBTTBE has also been successfully applied in the synthesis of radiometal-labeled peptide and antibody without observable transchelation with the non-radioactive Cu(I) catalyst.

Graphical abstract: Highly-efficient and versatile fluorous-tagged Cu(i)-catalyzed azide–alkyne cycloaddition ligand for preparing bioconjugates

Supplementary files

Article information

Article type
Communication
Submitted
14 Aug 2015
Accepted
25 Sep 2015
First published
25 Sep 2015

Chem. Commun., 2015,51, 17072-17075

Author version available

Highly-efficient and versatile fluorous-tagged Cu(I)-catalyzed azide–alkyne cycloaddition ligand for preparing bioconjugates

L. Sun, Y. Gai, C. J. Anderson and D. Zeng, Chem. Commun., 2015, 51, 17072 DOI: 10.1039/C5CC06858D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements