Higher-order human telomeric G-quadruplex DNA metalloenzyme catalyzed Diels–Alder reaction: an unexpected inversion of enantioselectivity modulated by K+ and NH4+ ions

Yinghao Li; Changhao Wang; Jingya Hao; Mingpan Cheng; Guoqing Jia; Can Li

doi:10.1039/C5CC05215G

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Higher-order human telomeric G-quadruplex DNA metalloenzyme catalyzed Diels–Alder reaction: an unexpected inversion of enantioselectivity modulated by K⁺ and NH₄⁺ ions†

Yinghao Li,^ab Changhao Wang,^a Jingya Hao,^ab Mingpan Cheng,^ab Guoqing Jia*^a and Can Li*^a

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* Corresponding authors

^a State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
E-mail: canli@dicp.ac.cn, gqjia@dicp.ac.cn

^b University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, China

Abstract

We report that K⁺ and NH₄⁺ present different allosteric activation for higher-order human telomeric G-quadruplex DNA metalloenzyme. The obtained major endo products of Diels–Alder reaction can be switched from one preferred configuration in K⁺ media (up to 92% ee) to its mirror configuration in NH₄⁺ media (up to −90% ee).

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Article information

DOI: https://doi.org/10.1039/C5CC05215G
Article type: Communication
Submitted: 25 Jun 2015
Accepted: 08 Jul 2015
First published: 08 Jul 2015

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Chem. Commun., 2015,51, 13174-13177

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Higher-order human telomeric G-quadruplex DNA metalloenzyme catalyzed Diels–Alder reaction: an unexpected inversion of enantioselectivity modulated by K⁺ and NH₄⁺ ions

Y. Li, C. Wang, J. Hao, M. Cheng, G. Jia and C. Li, Chem. Commun., 2015, 51, 13174 DOI: 10.1039/C5CC05215G

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