Al(OH)3 facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles

X. Cui; M. A. Green; P. J. Blower; D. Zhou; Y. Yan; W. Zhang; K. Djanashvili; D. Mathe; D. S. Veres; K. Szigeti

doi:10.1039/C5CC02259B

Al(OH)₃ facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles†

X. Cui,‡^a M. A. Green,*^ab P. J. Blower,*^a D. Zhou,^c Y. Yan,^d W. Zhang,^e K. Djanashvili,^e D. Mathe,^f D. S. Veres^g and K. Szigeti^g

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* Corresponding authors

^a King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor of Lambeth wing, St Thomas Hospital, London SE1 7EH, UK
E-mail: philip.blower@kcl.ac.uk, mark.a.green@kcl.ac.uk

^b King's College London, Department of Physics, Strand Campus, London, UK

^c Department of Mathematical Science, Loughborough University, Loughborough, UK

^d School of Chemistry, Nottingham University, Nottingham, UK

^e Department of Biotechnology, Delft University of Technology, Julianalaan, 136, Delft, The Netherlands

^f CROmed Ltd, Baross u. 91-95, Budapest, Hungary

^g Department of Biophysics and Radiation Biology, Semmelweis University, IX, Tüzoltó u. 37-47, Budapest, Hungary

Abstract

Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)₃-stabilised MnFe₂O₄ or Fe₃O₄ nanoparticles as precursors. They were readily and efficiently radiolabelled with ¹⁸F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with ⁶⁴Cu.

Chemical Communications

Al(OH)₃ facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles†

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Al(OH)₃ facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles

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