Issue 49, 2015
From the journal:

Chemical Communications

Detection of microRNA SNPs with ultrahigh specificity by using reduced graphene oxide-assisted rolling circle amplification†

Xiaoli Zhu,a   Yalan Shen,a   Jiepei Cao,a   Li Yin,b   Fangfang Ban,a   Yongqian Shu*b  and  Genxi Li*ac  

* Corresponding authors

a Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

b Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P. R. China
E-mail: shuyongqian@csco.org.cn

c State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China
E-mail: genxili@nju.edu.cn

Abstract

Here we report a reduced graphene oxide-assisted rolling circle amplification for the detection of miRNA SNPs. The difference of the signal of a miRNA SNP reaches 100 fold, a value over 10 times larger than some current methodologies, which allows the discrimination of a SNP even with the naked eye.

Graphical abstract: Detection of microRNA SNPs with ultrahigh specificity by using reduced graphene oxide-assisted rolling circle amplification

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Article information

DOI
https://doi.org/10.1039/C5CC02039E
Article type
Communication
Submitted
10 Mar 2015
Accepted
01 May 2015
First published
01 May 2015

Chem. Commun., 2015,51, 10002-10005

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Detection of microRNA SNPs with ultrahigh specificity by using reduced graphene oxide-assisted rolling circle amplification

X. Zhu, Y. Shen, J. Cao, L. Yin, F. Ban, Y. Shu and G. Li, Chem. Commun., 2015, 51, 10002 DOI: 10.1039/C5CC02039E

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