Issue 39, 2015
From the journal:

Chemical Communications

Target–aptamer binding triggered quadratic recycling amplification for highly specific and ultrasensitive detection of antibiotics at the attomole level†

Hongzhi Wang,a   Yu Wang,b   Su Liu,c   Jinghua Yu,a   Wei Xu,a   Yuna Guoa  and  Jiadong Huang*ab  

* Corresponding authors

a Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, P. R. China
E-mail: chm_huangjd@ujn.edu.cn

b College of Biological Sciences and Technology, University of Jinan, Jinan 250022, P. R. China

c College of Resources and Environment, University of Jinan, Jinan 250022, P. R. China

Abstract

A novel electrochemical aptasensor for ultrasensitive detection of antibiotics by combining polymerase-assisted target recycling amplification with strand displacement amplification with the help of polymerase and nicking endonuclease has been reported. This work is the first time that target–aptamer binding triggered quadratic recycling amplification has been utilized for electrochemical detection of antibiotics.

Graphical abstract: Target–aptamer binding triggered quadratic recycling amplification for highly specific and ultrasensitive detection of antibiotics at the attomole level

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Article information

DOI
https://doi.org/10.1039/C5CC01473E
Article type
Communication
Submitted
17 Feb 2015
Accepted
10 Apr 2015
First published
10 Apr 2015

Chem. Commun., 2015,51, 8377-8380

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Target–aptamer binding triggered quadratic recycling amplification for highly specific and ultrasensitive detection of antibiotics at the attomole level

H. Wang, Y. Wang, S. Liu, J. Yu, W. Xu, Y. Guo and J. Huang, Chem. Commun., 2015, 51, 8377 DOI: 10.1039/C5CC01473E

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