Water-based synthesis and processing of novel biodegradable elastomers for medical applications

Shan-hui Hsu; Kun-Che Hung; Ying-Yi Lin; Chiu-Hun Su; Hsi-Yi Yeh; U-Ser Jeng; Chun-Yi Lu; Shenghong A. Dai; Wei-En Fu; Jui-Che Lin

doi:10.1039/C4TB00572D

Water-based synthesis and processing of novel biodegradable elastomers for medical applications†

Shan-hui Hsu,*^a Kun-Che Hung,^a Ying-Yi Lin,^a Chiu-Hun Su,^b Hsi-Yi Yeh,^a U-Ser Jeng,^c Chun-Yi Lu,^a Shenghong A. Dai,^d Wei-En Fu^e and Jui-Che Lin^f

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* Corresponding authors

^a Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan
E-mail: shhsu@ntu.edu.tw

^b Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan

^c National Synchrotron Radiation Research Center, Hsinchu, Taiwan

^d Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan

^e National Measurement Laboratory, Center for Measurement Standards, Industrial Technology Research Institute of Taiwan/National Measurement Laboratory, Hsinchu, Taiwan

^f Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan

Abstract

Biodegradable elastomers in the form of polyurethane nanoparticles (NPs) were successfully synthesized based on the combinations of two hydrolysis-prone polyester diols by a green water-based process. The anionic nature of the polymers successfully rendered polyurethane NPs (30–50 nm) consisting of approximately 200–300 polymer chains. The mechanical properties and degradation rate could be adjusted by the types and ratios of the component oligodiols in the soft segment. We demonstrated the feasibility using these biodegradable NPs as building blocks to generate self-assembled morphologies in nanometric, micrometric, or bulk scale, bearing excellent elasticity and biocompatibility. The elastic NPs and their various assembled forms represent a series of smart biodegradable elastomers with potential medical applications.

Journal of Materials Chemistry B

Water-based synthesis and processing of novel biodegradable elastomers for medical applications†

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Water-based synthesis and processing of novel biodegradable elastomers for medical applications

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