Issue 37, 2014

Practical and scalable preparation of 2-methyleneglutaronitrile via an efficient and highly selective head-to-tail dimerization of acrylonitrile catalysed by low-loading of tricyclohexylphosphine

Abstract

By carefully evaluating the effect of solvent, ligand, temperature, and time, the commercially available tricyclohexylphosphine was found to be a particularly effective catalyst for head-to-tail dimerization of acrylonitrile, providing an efficient, scalable, and highly selective method for preparation of the useful 2-methyleneglutaronitrile with a low catalyst loading.

Graphical abstract: Practical and scalable preparation of 2-methyleneglutaronitrile via an efficient and highly selective head-to-tail dimerization of acrylonitrile catalysed by low-loading of tricyclohexylphosphine

Supplementary files

Article information

Article type
Communication
Submitted
29 Jan 2014
Accepted
11 Apr 2014
First published
11 Apr 2014

RSC Adv., 2014,4, 19122-19126

Practical and scalable preparation of 2-methyleneglutaronitrile via an efficient and highly selective head-to-tail dimerization of acrylonitrile catalysed by low-loading of tricyclohexylphosphine

L. Yu, J. Wang, X. Zhang, H. Cao, G. Wang, K. Ding, Q. Xu and M. Lautens, RSC Adv., 2014, 4, 19122 DOI: 10.1039/C4RA02810D

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