Issue 4, 2014
From the journal:

Organic Chemistry Frontiers

The redox-A3 reaction

Daniel Seidela  

a Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
E-mail: seidel@rutchem.rutgers.edu

Abstract

This highlight details the recent emergence of a new type of A3 reaction (three-component condensation of an amine, an aldehyde and an alkyne). In contrast to the classic A3 coupling process, the redox-A3 reaction incorporates an iminium isomerization step and leads to amine α-alkynylation. The overall transformation is redox-neutral by virtue of a combined reductive N-alkylation/oxidative C–H bond functionalization.

Graphical abstract: The redox-A3 reaction

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Article information

DOI
https://doi.org/10.1039/C4QO00022F
Article type
Highlight
Submitted
21 Jan 2014
Accepted
12 Mar 2014
First published
13 Mar 2014

Org. Chem. Front., 2014,1, 426-429

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The redox-A3 reaction

D. Seidel, Org. Chem. Front., 2014, 1, 426 DOI: 10.1039/C4QO00022F

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