Issue 11, 2015
From the journal:

Organic & Biomolecular Chemistry

Fluorination of 2-substituted benzo[b]furans with Selectfluor™†

Mingliang Wang,a   Xixi Liu,a   Lu Zhou,b   Jidong Zhu*c  and  Xun Sun*ad  

* Corresponding authors

a Department of Natural Products Chemistry, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
E-mail: sunxunf@shmu.edu.cn
Fax: +8621 51980003

b Department of Medicinal Chemistry, Fudan University, 826 Zhangheng Rd., Shanghai 201203, China

c Interdisciplinary Research Center on Biology and Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: zhujd@sioc.ac.cn

d Shanghai Key Laboratory of Clinical Geriatric Medicine, 221 West Yanan Road, Shanghai 200040, China

Abstract

An efficient protocol was developed to access 3-fluoro-2-hydroxy-2-substituted benzo[b]furans with Selectfluor™ as the fluorinating reagent in MeCN and water. By utilizing SOCl2/Py as the dehydrating agent, the compounds above were readily converted to 3-fluorinated, 2-substituted benzo[b]furans in high yields.

Graphical abstract: Fluorination of 2-substituted benzo[b]furans with Selectfluor™

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Article information

DOI
https://doi.org/10.1039/C4OB02691H
Article type
Communication
Submitted
30 Dec 2014
Accepted
28 Jan 2015
First published
28 Jan 2015

Org. Biomol. Chem., 2015,13, 3190-3193

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Fluorination of 2-substituted benzo[b]furans with Selectfluor™

M. Wang, X. Liu, L. Zhou, J. Zhu and X. Sun, Org. Biomol. Chem., 2015, 13, 3190 DOI: 10.1039/C4OB02691H

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