Issue 4, 2015
From the journal:

Organic & Biomolecular Chemistry

Catalyst-free synthesis of 2-aryl-1,2-dihydro-quinazolin-4(1H)-thiones from 2-aminobenzothio-amides and aldehydes in water†

Stefan Oschatz,ab   Tom Brunzel,a   Xiao-Feng Wu*ac  and  Peter Langer*ab  

* Corresponding authors

a Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany
E-mail: xiao-feng.wu@catalysis.de

b Universität Rostock, Institut für Chemie, Albert-Einstein-Str. 3a, Rostock, Germany
E-mail: peter.langer@uni-rostock.de

c Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province, People's Republic of China

Abstract

2-Dihydroquinazolin-4(1H)-thiones were prepared in up to excellent yields from 2-aminobenzothioamides and aldehydes. The reaction is carried out in water without the use of any catalyst or promoter. The sulfur-containing substrate can be obtained easily by thiation of the corresponding nitrile by solid sodium hydrosulfide.

Graphical abstract: Catalyst-free synthesis of 2-aryl-1,2-dihydro-quinazolin-4(1H)-thiones from 2-aminobenzothio-amides and aldehydes in water

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Article information

DOI
https://doi.org/10.1039/C4OB02207F
Article type
Paper
Submitted
17 Oct 2014
Accepted
13 Nov 2014
First published
13 Nov 2014

Org. Biomol. Chem., 2015,13, 1150-1158

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Catalyst-free synthesis of 2-aryl-1,2-dihydro-quinazolin-4(1H)-thiones from 2-aminobenzothio-amides and aldehydes in water

S. Oschatz, T. Brunzel, X. Wu and P. Langer, Org. Biomol. Chem., 2015, 13, 1150 DOI: 10.1039/C4OB02207F

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