Issue 45, 2014
From the journal:

Organic & Biomolecular Chemistry

Synthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile†

Wandi Zhang,‡a   Christopher W. Haskins,‡a   Yang Yanga  and  Mingji Dai*a  

* Corresponding authors

a Department of Chemistry and Center for Cancer Research, Purdue University, 720 Clinic Drive, West Lafayette, IN 47907, USA
E-mail: mjdai@purdue.edu

Abstract

Palladium-catalyzed synthesis of nitriles from amides has been described. Two similar, but complementary reaction conditions have been identified to convert various amides including α,β,γ,δ-unsaturated amides, cinnamides, aromatic amides and alkyl amides to the corresponding nitriles in good to excellent yield.

Graphical abstract: Synthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile

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Article information

DOI
https://doi.org/10.1039/C4OB01825G
Article type
Communication
Submitted
26 Aug 2014
Accepted
07 Oct 2014
First published
07 Oct 2014

Org. Biomol. Chem., 2014,12, 9109-9112

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Synthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile

W. Zhang, C. W. Haskins, Y. Yang and M. Dai, Org. Biomol. Chem., 2014, 12, 9109 DOI: 10.1039/C4OB01825G

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