Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine

Yuko Murakami; Rina Suzuki; Hiroto Yanuma; Jiangtao He; Shuren Ma; Gerard M. Turino; Yong Y. Lin; Toyonobu Usuki

doi:10.1039/C4OB01438C

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Synthesis and LC-MS/MS analysis of desmosine-CH₂, a potential internal standard for the degraded elastin biomarker desmosine†

Yuko Murakami,^a Rina Suzuki,^a Hiroto Yanuma,^a Jiangtao He,^b Shuren Ma,^b Gerard M. Turino,^b Yong Y. Lin^b and Toyonobu Usuki*^a

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* Corresponding authors

^a Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan
E-mail: t-usuki@sophia.ac.jp
Fax: +81 3 3238 3361
Tel: +81 3 3238 3446

^b Roosevelt Hospital Center, Mount Sinai School of Medicine, 432W 58th St, New York, NY 10019, USA

Abstract

Desmosine-CH₂, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH₂ was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH₂ was also achieved.

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Article information

DOI: https://doi.org/10.1039/C4OB01438C
Article type: Paper
Submitted: 09 Jul 2014
Accepted: 06 Oct 2014
First published: 07 Oct 2014

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Org. Biomol. Chem., 2014,12, 9887-9894

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Synthesis and LC-MS/MS analysis of desmosine-CH₂, a potential internal standard for the degraded elastin biomarker desmosine

Y. Murakami, R. Suzuki, H. Yanuma, J. He, S. Ma, G. M. Turino, Y. Y. Lin and T. Usuki, Org. Biomol. Chem., 2014, 12, 9887 DOI: 10.1039/C4OB01438C

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Organic & Biomolecular Chemistry