Issue 15, 2015
From the journal:

Nanoscale

Imaging of drug loading distributions in individual microspheres of calcium silicate hydrate – an X-ray spectromicroscopy study†

Xiaoxuan Guo,‡a   Zhiqiang Wang,‡a   Jin Wu,b   Jian Wang,c   Ying-Jie Zhu*b  and  Tsun-Kong Sham*a  

* Corresponding authors

a Department of Chemistry, University of Western Ontario, London, Ontario N6A 5B7, Canada
E-mail: tsham@uwo.ca

b Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
E-mail: y.j.zhu@mail.sic.ac.cn

c Canadian Light Source, Saskatoon, Saskatchewan S7N 2V3, Canada

Abstract

Imaging is one of the most direct and ideal ways to track drug loading distributions in drug carriers on the molecular level, which will facilitate the optimization of drug carriers and drug loading capacities. Herein, we report the mapping of an individual mesoporous calcium silicate hydrate (CSH) microsphere before and after the loading of ibuprofen (IBU) and the interactions between drug carriers and drug molecules simultaneously by scanning transmission X-ray microscopy (STXM). Nanoscaled X-ray absorption near edge structure (XANES) spectroscopy clearly indicates that IBU is bonded to calcium and silicate sites via carboxylic acid groups. More importantly, STXM has been successfully used to determine the absolute thickness of IBU, revealing its distribution in the CSH microsphere.

Graphical abstract: Imaging of drug loading distributions in individual microspheres of calcium silicate hydrate – an X-ray spectromicroscopy study

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Article information

DOI
https://doi.org/10.1039/C4NR07471H
Article type
Paper
Submitted
17 Dec 2014
Accepted
11 Mar 2015
First published
16 Mar 2015

Nanoscale, 2015,7, 6767-6773

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Imaging of drug loading distributions in individual microspheres of calcium silicate hydrate – an X-ray spectromicroscopy study

X. Guo, Z. Wang, J. Wu, J. Wang, Y. Zhu and T. Sham, Nanoscale, 2015, 7, 6767 DOI: 10.1039/C4NR07471H

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