MRI nanoprobes based on chemical exchange saturation transfer: LnIII chelates anchored on the surface of mesoporous silica nanoparticles

Giuseppe Ferrauto; Fabio Carniato; Lorenzo Tei; He Hu; Silvio Aime; Mauro Botta

doi:10.1039/C4NR02753A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

MRI nanoprobes based on chemical exchange saturation transfer: Ln^III chelates anchored on the surface of mesoporous silica nanoparticles†

Giuseppe Ferrauto,^a Fabio Carniato,^b Lorenzo Tei,^b He Hu,^a Silvio Aime*^a and Mauro Botta*^b

Author affiliations

* Corresponding authors

^a Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza, 52, Torino, Italy
E-mail: silvio.aime@unito.it

^b Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro”, Viale T. Michel 11, Alessandria, Italy
E-mail: mauro.botta@unipmn.it

Abstract

The formation of ternary complexes between neutral Ln^III–DO3A chelates anchored on MCM-41 mesoporous silica nanoparticles (MSNs) and silanol groups on the surface allows obtaining highly efficient chemical exchange saturation transfer (CEST) MRI nanoprobes. These new probes achieve excellent sensitivity in the μM range (per Ln^III ion), significantly greater than that of other paramagnetic CEST nanosystems such as dendrimers or micelles and three orders of magnitude higher than that of the corresponding molecular agents.

Download options Please wait...

Supplementary files

Supplementary information PDF (1341K)

Article information

DOI: https://doi.org/10.1039/C4NR02753A
Article type: Communication
Submitted: 19 May 2014
Accepted: 17 Jun 2014
First published: 19 Jun 2014

Download Citation

Nanoscale, 2014,6, 9604-9607

Author version available

Download author version (PDF)

Permissions

Request permissions

MRI nanoprobes based on chemical exchange saturation transfer: Ln^III chelates anchored on the surface of mesoporous silica nanoparticles

G. Ferrauto, F. Carniato, L. Tei, H. Hu, S. Aime and M. Botta, Nanoscale, 2014, 6, 9604 DOI: 10.1039/C4NR02753A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Nanoscale