A convenient palladium-catalyzed carbonylative synthesis of 4(3H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo(CO)6 as a multiple promoter

Lin He; Muhammad Sharif; Helfried Neumann; Matthias Beller; Xiao-Feng Wu

doi:10.1039/C4GC00801D

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A convenient palladium-catalyzed carbonylative synthesis of 4(3H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo(CO)₆ as a multiple promoter†

Lin He,‡^a Muhammad Sharif,‡^ab Helfried Neumann,^a Matthias Beller^a and Xiao-Feng Wu*^ac

Author affiliations

* Corresponding authors

^a Leibniz-Institut für Katalyse an der Universität Rostock, e.V. Albert-Einstein-Str. 29a, 18059 Rostock, Germany

^b Department of Chemistry, Comsats Institute of Information Technology, Abbottabad, Pakistan

^c Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province, People's Republic of China
E-mail: xiao-feng.wu@catalysis.de

Abstract

A novel and convenient procedure for the synthesis of quinazolinones has been developed. Using 2-bromoformanilides and organo nitros as substrates and Mo(CO)₆ as a multiple promoter, the desired products were isolated in moderate to excellent yields in the presence of a palladium catalyst. Here, Mo(CO)₆ was not only a CO source, but also a nitro compound reducing reagent and a cyclization promoter.

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Article information

DOI: https://doi.org/10.1039/C4GC00801D
Article type: Communication
Submitted: 02 May 2014
Accepted: 25 Jun 2014
First published: 26 Jun 2014

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Green Chem., 2014,16, 3763-3767

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A convenient palladium-catalyzed carbonylative synthesis of 4(3H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo(CO)₆ as a multiple promoter

L. He, M. Sharif, H. Neumann, M. Beller and X. Wu, Green Chem., 2014, 16, 3763 DOI: 10.1039/C4GC00801D

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