Issue 97, 2014
From the journal:

Chemical Communications

A folic acid conjugated silica–titania porous hollow nanosphere for improved topical photodynamic therapy†

Yoonsun Jang,a   Sojin Kim,a   Wan-Kyu Oh,a   Chanhoi Kim,a   Inkyu Leea  and  Jyongsik Jang*a  

* Corresponding authors

a World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2) School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, Korea
E-mail: jsjang@plaza.snu.ac.kr
Fax: +82 2 888 1604
Tel: +82 2 880 7069

Abstract

The folic acid conjugated hollow nanosphere is used to encapsulate protoporphyrin IX and is utilized for photodynamic therapy. This system represents a 3.33 times higher photodynamic efficiency than previous protoporphyrin IX-based systems. The result proposes a new opportunity for effective photodynamic therapy of folate receptor positive tumor cells.

Graphical abstract: A folic acid conjugated silica–titania porous hollow nanosphere for improved topical photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C4CC07457B
Article type
Communication
Submitted
22 Sep 2014
Accepted
08 Oct 2014
First published
14 Oct 2014

Chem. Commun., 2014,50, 15345-15347

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A folic acid conjugated silica–titania porous hollow nanosphere for improved topical photodynamic therapy

Y. Jang, S. Kim, W. Oh, C. Kim, I. Lee and J. Jang, Chem. Commun., 2014, 50, 15345 DOI: 10.1039/C4CC07457B

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