I2-catalyzed oxidative C(sp3)–H/S–H coupling: utilizing alkanes and mercaptans as the nucleophiles

Jiwen Yuan; Xu Ma; Hong Yi; Chao Liu; Aiwen Lei

doi:10.1039/C4CC05661B

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I₂-catalyzed oxidative C(sp³)–H/S–H coupling: utilizing alkanes and mercaptans as the nucleophiles†

Jiwen Yuan,^a Xu Ma,^a Hong Yi,^a Chao Liu

^a and Aiwen Lei*^ab

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* Corresponding authors

^a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China
E-mail: aiwenlei@whu.edu.cn
Fax: +86-27-68754067
Tel: +86-27-68754672

^b National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, Jiangxi, P. R. China

Abstract

By using alkanes and mercaptans as the nucleophiles with di-tert-butyl peroxide (DTBP) as the oxidant, I₂-catalyzed oxidative C(sp³)–H/S–H coupling was achieved. This protocol provides a novel process to construct C(sp³)–S bonds from commercially available hydrocarbons and mercaptans.

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Article information

DOI: https://doi.org/10.1039/C4CC05661B
Article type: Communication
Submitted: 22 Jul 2014
Accepted: 20 Sep 2014
First published: 26 Sep 2014

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Chem. Commun., 2014,50, 14386-14389

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I₂-catalyzed oxidative C(sp³)–H/S–H coupling: utilizing alkanes and mercaptans as the nucleophiles

J. Yuan, X. Ma, H. Yi, C. Liu and A. Lei, Chem. Commun., 2014, 50, 14386 DOI: 10.1039/C4CC05661B

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