Issue 81, 2014
From the journal:

Chemical Communications

Functionalised nanoparticles complexed with antibiotic efficiently kill MRSA and other bacteria†

Lei Wang,a   Yung Pin Chen,b   Kristen P. Miller,b   Brandon M. Cash,a   Shonda Jones,b   Steven Glenn,b   Brian C. Benicewiczac  and  Alan W. Decho*bc  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA

b Department of Environmental Health Sciences, University of South Carolina, Columbia, SC 29208, USA
E-mail: awdecho@mailbox.sc.edu

c USC NanoCenter, University of South Carolina, Columbia, SC 29208, USA

Abstract

Antibiotic-resistant bacterial infections are a vexing global health problem and have rendered ineffective many previously-used antibiotics. Here we demonstrate that antibiotic-linkage to surface-functionalized silica nanoparticles (sNP) significantly enhances their effectiveness against Escherichia coli, and Staphylococcus aureus, and even methicillin-resistant S. aureus (MRSA) strains that are resistant to most antibiotics. The commonly-used antibiotic penicillin-G (PenG) was complexed to dye-labeled sNPs (15 nm diameter) containing carboxyl groups located as either surface-functional groups, or on polymer-chains extending from surfaces. Both sNPs configurations efficiently killed bacteria, including MRSA strains. This suggests that activities of currently-ineffective antibiotics can be restored by nanoparticle-complexation and used to avert certain forms of antibiotic-resistance.

Graphical abstract: Functionalised nanoparticles complexed with antibiotic efficiently kill MRSA and other bacteria

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Article information

DOI
https://doi.org/10.1039/C4CC04936E
Article type
Communication
Submitted
27 Jun 2014
Accepted
14 Aug 2014
First published
14 Aug 2014

Chem. Commun., 2014,50, 12030-12033

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Functionalised nanoparticles complexed with antibiotic efficiently kill MRSA and other bacteria

L. Wang, Y. P. Chen, K. P. Miller, B. M. Cash, S. Jones, S. Glenn, B. C. Benicewicz and A. W. Decho, Chem. Commun., 2014, 50, 12030 DOI: 10.1039/C4CC04936E

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