Issue 76, 2014
From the journal:

Chemical Communications

Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles†

Lijun Wang,*a   Yue Min,‡ab   Doudou Xu,‡a   Fengjiao Yu,c   Wuzong Zhouc  and  Alfred Cuschieria  

* Corresponding authors

a Institute for Medical Science and Technology, College of Medicine, Dentistry and Nursing, University of Dundee, Dundee DD2 1FD, UK
E-mail: l.y.wang@dundee.ac.uk

b Centre for Medical Device Evaluation, China Food and Drug Administration, Beijing 100044, China

c School of Chemistry, University of St Andrews, St Andrews KY16 9ST, UK

Abstract

We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

Graphical abstract: Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC03082F
Article type
Communication
Submitted
25 Apr 2014
Accepted
30 Jul 2014
First published
30 Jul 2014

Chem. Commun., 2014,50, 11147-11150

Author version available

Download author version (PDF)

Permissions

Request permissions

Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

L. Wang, Y. Min, D. Xu, F. Yu, W. Zhou and A. Cuschieri, Chem. Commun., 2014, 50, 11147 DOI: 10.1039/C4CC03082F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements