Issue 35, 2013
From the journal:

Journal of Materials Chemistry B

Electrospun Ginsenoside Rg3/poly(lactic-co-glycolic acid) fibers coated with hyaluronic acid for repairing and inhibiting hypertrophic scars

Liying Cheng,†ac   Xiaoming Sun,†c   Bin Li,ab   Changmin Hu,b   Huilin Yang,ab   Yuguang Zhang*c  and  Wenguo Cui*ab  

* Corresponding authors

a Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi St, Suzhou, Jiangsu 215006, People’s Republic of China
E-mail: wgcui80@hotmail.com
Fax: +86-512-67781420
Tel: +86-512-67781420

b Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215007, People's Republic of China

c Department of Plastic and Reconstructive Surgery, Ninth People's Hospital affiliated to Medical School of Shanghai Jiao Tong University, 639 Zhi Zao Ju Road, Shanghai 200011, The People's Republic of China
E-mail: zhangyg18@126.com
Fax: +86-21-63089562
Tel: +86-21-63089562

Abstract

Studies have explored many approaches to prevent and treat hypertrophic scars. However, most of them inhibit hypertrophic scars after their formation, without taking into account repairing tissue damage in the early stage and inhibiting scar hyperplasia in the late stage through combining treatments. In this study, Ginsenoside Rg3 (Rg3) loaded poly(D,L-lactide-co-glycolide) (PLGA) electrospun fibrous scaffolds were prepared by a co-solvent electrospinning method, and then hyaluronic acid (HA) was coated on the surface of the drug-loaded electrospun fibers by a pressure-driven permeation (PDP) wrapped method. The hydrophilic Rg3/PLGA/HA electrospun fibrous scaffolds showed the effect of combining treatments of promoting wound healing in the early stage and inhibiting scar hyperplasia in the late stage. The improved hydrophilicity together with a proper porous structure, a stable fibrous structure, durable mechanical properties and a similar drug release model suggested that the Rg3/PLGA electrospun scaffold coated with HA via PDP has great potential for drug-loaded tissue engineering scaffolds. The in vivo animal results showed that the Rg3/PLGA/HA could promote wound healing earlier and significantly inhibit scar hyperplasia compared to other control groups from macroscopic, histologic evaluation, and expression of collagen type I. The Rg3/PLGA/HA electrospun fibrous scaffolds open a new combined therapeutic approach for inhibiting hypertrophic scars.

Graphical abstract: Electrospun Ginsenoside Rg3/poly(lactic-co-glycolic acid) fibers coated with hyaluronic acid for repairing and inhibiting hypertrophic scars

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Article information

DOI
https://doi.org/10.1039/C3TB20441C
Article type
Paper
Submitted
28 Mar 2013
Accepted
03 Jul 2013
First published
03 Jul 2013

J. Mater. Chem. B, 2013,1, 4428-4437

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Electrospun Ginsenoside Rg3/poly(lactic-co-glycolic acid) fibers coated with hyaluronic acid for repairing and inhibiting hypertrophic scars

L. Cheng, X. Sun, B. Li, C. Hu, H. Yang, Y. Zhang and W. Cui, J. Mater. Chem. B, 2013, 1, 4428 DOI: 10.1039/C3TB20441C

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