Issue 19, 2014
From the journal:

RSC Advances

Amphiphilic block copolymer micelles with fluorescence as nano-carriers for doxorubicin delivery

Jiucun Chenab  and  Mingzhu Liu*a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China
E-mail: mzliu@lzu.edu.cn
Fax: +86-931-8912582
Tel: +86-931-8912387

b Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing, P. R. China
E-mail: chenjc@swu.edu.cn

Abstract

Well-defined and nontoxic core–shell polymeric micelles, containing fluorescence units, were employed for efficient drug delivery of doxorubicin (DOX). The self-assembled structures were generated from triblock copolymers of poly(ε-caprolactone)-block-poly(glycidyl methacrylate)-block-poly(poly(ethylene glycol)methyl ether methacrylate) (PCL-b-PGMA-b-P(PEGMA)) with fluorescence units. Various experiments like structural characterization, fluorescence properties, cell viability studies, encapsulation studies, measuring cytotoxicity against fibroblasts and bladder cancer cells are performed on these polymeric micelles. All of these results demonstrate that these self-assembled micelles may be promising carriers for intravesical delivery of DOX for bladder cancer therapy.

Graphical abstract: Amphiphilic block copolymer micelles with fluorescence as nano-carriers for doxorubicin delivery

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C3RA47026A
Article type
Paper
Submitted
26 Nov 2013
Accepted
21 Jan 2014
First published
28 Jan 2014

RSC Adv., 2014,4, 9684-9692

Permissions

Request permissions

Amphiphilic block copolymer micelles with fluorescence as nano-carriers for doxorubicin delivery

J. Chen and M. Liu, RSC Adv., 2014, 4, 9684 DOI: 10.1039/C3RA47026A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements